Evidence for the Cure of HIV Infection by CCR5∆32/∆32 Stem Cell Transplantation

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Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation.

HIV entry into CD4(+) cells requires interaction with a cellular receptor, generally either CCR5 or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral replication remained absent despite discontinuation of antiretroviral therapy after transplantation with CCR5Δ32/Δ32 stem cells. However, it was expected that the long-lived viral reservoir would lead to HIV rebo...

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ژورنال

عنوان ژورنال: Journal of Human Virology & Retrovirology

سال: 2014

ISSN: 2373-6453

DOI: 10.15406/jhvrv.2014.01.00008